What is Trimix?
Trimix is a compounded sterile injection typically containing three medications—alprostadil, papaverine, and phentolamine—used under clinician guidance to help produce an erection by improving blood flow in penile tissue. Formulations and strengths can vary by compounding pharmacy and clinician judgment. Trimix is not FDA-approved as a finished product (because it is compounded for an individual patient), but its ingredients are FDA-approved when used in other contexts.
How Trimix works
Each component targets a part of the erectile pathway:
- Alprostadil (PGE-1): Relaxes smooth muscle in the corpus cavernosum.
- Papaverine: Non-selective PDE inhibitor that supports vasodilation.
- Phentolamine: Alpha-adrenergic blocker that reduces constriction of blood vessels.
Together, they relax smooth muscle and widen blood vessels locally, promoting firm erections typically within minutes when dosing and technique are correct.
Results & typical timeline
- Onset: Often within 5–15 minutes after injection training and correct use.
- Duration: Varies based on dose and individual factors; your clinician will set limits and a titration plan.
- Consistency: Many patients report reliable results once an effective, safe dose is established through clinical titration.
Important: Actual results vary. Dosing is individualized. Always follow your clinician’s plan and safety instructions.
What patients often report (themes)
Common positive themes reported to clinics include: fast onset, strong firmness, and effectiveness even when oral ED medications weren’t sufficient.
Common challenges include: learning injection technique, sensitivity at the injection site, and needing a few titration steps to find the right dose.
Notes reflect frequent themes heard in clinical practice and patient education settings; they are not individual testimonials or guarantees of outcome.
Pros & considerations
Potential advantages
- Rapid, predictable onset after proper training.
- Can work for men who didn’t respond to pills.
- Dose can be clinically adjusted (within safety limits).
Things to consider
- Requires injection technique and sterile handling.
- Possible adverse effects (see Safety section).
- Not appropriate for everyone; prescriptions are not guaranteed.
Safety, side effects & precautions
Potential side effects may include penile pain or burning, bruising at the site, dizziness, flushing, or temporary blood-pressure changes. Seek urgent care for an erection lasting >4 hours (priapism). Tell your clinician about penile curvature/Peyronie’s disease, blood disorders (e.g., sickle cell disease), leukemia, anticoagulant use, or bleeding risks. Do not combine with other ED therapies unless instructed by your clinician.
Who may be a candidate?
Adults with erectile dysfunction who are appropriate based on medical history, medication review, and state regulations. Your clinician will determine eligibility after evaluation and, if indicated, training.
How to get started
- Complete the secure intake: Start your ED evaluation.
- Clinician review (and telehealth visit if needed).
- If appropriate, dosing plan and injection training are provided. Dispensing is through a state-licensed U.S. compounding pharmacy.
Quick FAQs
How fast will Trimix work for me?
Many patients experience onset in 5–15 minutes after correct use. Your results depend on dose, technique, and individual factors.
Is Trimix safe?
Trimix can be used safely when prescribed appropriately with proper dosing and technique. Risks include priapism and local side effects; emergency instructions are part of training.
Can I still use sildenafil or tadalafil?
Do not combine therapies unless your clinician directs you to do so. Combining ED treatments can increase risks.
Important: Trimix is a compounded medication and therefore not FDA-approved as a finished drug product. Prescriptions are issued only when clinically appropriate after a valid clinician-patient relationship is established.